(3S,4S)-3-tert-Butoxycarbonylamino-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester synthesis

2synthesis methods

Product Name:(3S,4S)-3-tert-Butoxycarbonylamino-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
CAS Number:708273-50-1
Molecular formula:C17H24N2O5
Molecular Weight:336.38

6-Oxa-3-azabicyclo[3.1.0]hexane-3-carboxylic acid, phenylMethyl ester

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(3S,4S)-3-tert-Butoxycarbonylamino-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

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Yield:-

Steps:

Multi-step reaction with 4 steps
1: ethanol / 48 h / 90 °C / Sealed tube
2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane
3: dichloromethane / 24 h / 20 °C
4: triethylamine / 1,4-dioxane / 84 h / 30 °C / Enzymatic reaction

References:

Rodríguez-Rodríguez, Jesús A.;Quijada, F. Javier;Brieva, Rosario;Rebolledo, Francisca;Gotor, Vicente [Tetrahedron,2013,vol. 69,# 26,p. 5407 - 5412]

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1203566-76-0 Synthesis

(3R,4R)-3-tert-Butoxycarbonylamino-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

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708273-50-1
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References