Propanedioic acid, 2-(4-aminophenyl)-, 1,3-diethyl ester synthesis
- Product Name:Propanedioic acid, 2-(4-aminophenyl)-, 1,3-diethyl ester
- CAS Number:70875-69-3
- Molecular formula:C13H17NO4
- Molecular Weight:251.28
10565-13-6
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70875-69-3
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Yield:70875-69-3 96.67%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in ethanol at 20; for 2 h;
Steps:
F.2 Step 2: Preparation of diethyl 2-(4-aminophenyl)malonate (Intermediate 6-b):
[0219] To a solution of 1,3-diethyl 2-(4-nitrophenyl)propanedioate (2.2 g, 7.822 mmol,1 equiv) in ethanol (25 mL) was added Pd/C (1.10 g, 50%w/w). The resulting mixture was stirred at r.t. for 2 h under hydrogen atmosphere, filtered to remove the solids, and the filtrate was concentrated under reduced pressure to give 1.9 g of 1,3-diethyl 2-(4-aminophenyl)propanedioate (96.67%) as a yellow oil. LRMS (ES) m/z 252[M+H]
References:
WO2021/159015,2021,A1 Location in patent:Paragraph 0219
586-78-7
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70875-69-3
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105-53-3
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70875-69-3
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