ChemicalBook CAS DataBase List 5,7-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE

5,7-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE synthesis

5synthesis methods

Product Name:5,7-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE
CAS Number:7135-02-6
Molecular formula:C7H9N5
Molecular Weight:163.18

Carbamic acid, N-[[(4,6-dimethyl-2-pyrimidinyl)amino]thioxomethyl]-, ethyl ester

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5,7-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YLAMINE

7135-02-6
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$75.00/100mg

Yield:7135-02-6 92.1%

Reaction Conditions:

Stage #1: ethyl N-carbamatewith hydroxylamine hydrochloride in ethanol at 60; for 0.5 h;
Stage #2: with triethylamine in ethanol; for 5 h;Reflux;

Steps:

Synthesis of 2-Amino-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (4b):

General procedure: A solution of 3a (114.5 g,0.4 mol) and hydroxylamine hydrochloride (40.3 g, 0.58 mol) in EtOH (600 mL) was stirred vigorously for 0.5 h at 60 C, then triethylamine (58.7 g, 0.58 mol) was added dropwise into the mixture. The resultant mixture was refluxed for 5 h, then cooling to the room temperature. The white solid product of4a was collected by filtration and washed using 200 mL water, yield 71.4 g (91.5%);

References:

Ma, Yi-Chao;Yu, Ying-Hui;Hou, Guang-Feng;Huang, Ji-Han;Gao, Jin-Sheng [Heterocycles,2016,vol. 92,# 5,p. 829 - 843]