ChemicalBook CAS DataBase List 4-AMINO-2,3,5,6-TETRAFLUORO-BENZOIC ACID METHYL ESTER

4-AMINO-2,3,5,6-TETRAFLUORO-BENZOIC ACID METHYL ESTER synthesis

9synthesis methods

Product Name:4-AMINO-2,3,5,6-TETRAFLUORO-BENZOIC ACID METHYL ESTER
CAS Number:715-37-7
Molecular formula:C8H5F4NO2
Molecular Weight:223.12

122590-75-4 Synthesis

methyl 4-azido-2,3,5,6-tetrafluorobenzoate

122590-75-4
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4-AMINO-2,3,5,6-TETRAFLUORO-BENZOIC ACID METHYL ESTER

715-37-7
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Yield:715-37-7 95%

Reaction Conditions:

with 2-(bis(4-methoxyphenyl)phosphanyl)-5-methylbenzenesulfonamide in tetrahydrofuran at 30; for 3 h;Inert atmosphere;Staudinger Azide Reduction;

Steps:

General Procedure A (for the substrates 1a-1m)

General procedure: Under a N2 atmosphere, the correspondingorganic azide (1.00 mmol, 1.0 equiv) was dissolved in anhydrous tetrahydrofuran(10 mL), followed by the addition of 2c (1.10 mmol, 1.1 equiv). The mixture was stirredat 30 C for 3 h. Upon completion, the mixture was concentrated in vacuo and the crudeproduct was purified by flash column chromatography.

References:

Li, Xingzhuo;Wang, Zhenguo;Luo, Wenjun;Wang, Zixu;Yin, Keshu;Li, Le [Molecules,2022,vol. 27,# 17,art. no. 5707]

67-56-1 Synthesis