ChemicalBook CAS DataBase List 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE HYDROCHLORIDE 98

1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE HYDROCHLORIDE 98 synthesis

2synthesis methods

Product Name:1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE HYDROCHLORIDE 98
CAS Number:71617-20-4
Molecular formula:C13H17ClN2O
Molecular Weight:252.7399

1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE HYDROCHLORIDE 98

71617-20-4
43 suppliers
$22.00/5g

1262988-77-1 Synthesis

1-Benzyl-4-hydroxypiperidine-4-carboxylic acid hydrochloride

1262988-77-1
28 suppliers
$41.00/100mg

Yield:1262988-77-1 96%

Reaction Conditions:

with hydrogenchloride;water for 16 h;Reflux;

Steps:

4.1

Step 11-Benzyl-4-hydroxy-piperidine-4-carboxylic acid, hydrochloride A mixture of 8 g (32 mmol) 1-benzyl-4-cyano-4-hydroxypiperidine hydrochloride and 15.8 mL HCl (37%) was heated to reflux for 16 h. The solution was cooled to room temperature and the white precipitate was filtered off and washed with iso-propanol. The filtrate was evaporated to yield 9.71 g (96%) of the title compound as white waxy solid which was used without further purification. MS (m/e): 234.4[(MH)-].

References:

US2011/28515,2011,A1 Location in patent:Page/Page column 17

71617-20-4
43 suppliers
$22.00/5g

1-Benzyl-4-hydroxypiperidine-4-carboxamide

27771-25-1
10 suppliers
$111.00/500mg

References

1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE HYDROCHLORIDE 98 Related Search:

Piperidine hydrochloride 4-Hydroxypiperidine hydrochloride 1-Benzyl-4-hydroxypiperidine