Methyl 6-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxyIate synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 48.5 h / 0 - 20 °C
2: acetonitrile / 6 h / 40 °C
3: hydrogen; platinum(IV) oxide / methanol

References:

Blackburn, Christopher;Barrett, Cynthia;Chin, Janice;Garcia, Kris;Gigstad, Kenneth;Gould, Alexandra;Gutierrez, Juan;Harrison, Sean;Hoar, Kara;Lynch, Chrissie;Rowland, R. Scott;Tsu, Chris;Ringeling, John;Xu, He [Journal of Medicinal Chemistry,2013,vol. 56,# 18,p. 7201 - 7211]