2,2,2-TRICHLORO-1-(4-CHLORO-1H-PYRROL-2-YL)ETHANONE synthesis
- Product Name:2,2,2-TRICHLORO-1-(4-CHLORO-1H-PYRROL-2-YL)ETHANONE
- CAS Number:72652-31-4
- Molecular formula:C6H3Cl4NO
- Molecular Weight:246.91
35302-72-8
176 suppliers
$10.00/5g
72652-31-4
9 suppliers
$808.88/1G
Yield:72652-31-4 83.74%
Reaction Conditions:
with ferric(III) chloride;sulfuryl dichloride in dichloromethane at 0 - 25; for 17 h;Solvent;Reagent/catalyst;Temperature;
Steps:
1-7 Example 7
100g of 2-trichloroacetylpyrrole,Mix 500mL dichloromethane and 15g ferric chloride,Then, 75 g of sulfonyl chloride was added at 0 °C. After the addition, the mixture was stirred at 0 °C for 2 h, then heated to 25 °C and reacted for 15 h. The reaction progress was monitored by gas chromatography. After the reaction was completed, 500 mL of ice water was added to quench the reaction, and then the pH value was adjusted to 7 with saturated sodium bicarbonate solution; the aqueous phase and the organic phase were separated, 10 g of anhydrous sodium sulfate was added to the organic phase for drying and dehydration, and the anhydrous sodium sulfate was removed by filtration. , and finally the solvent was removed by rotary evaporation at 40°C to obtain 4-chloro-2-trichloroacetylpyrrole. The yield was 83.74% and the purity was 92.65%.
References:
CN114456099,2022,A Location in patent:Paragraph 0040; 0042-0043; 0046-0047; 0049-0050; 0052; ...
35302-72-8
176 suppliers
$10.00/5g
72652-31-4
9 suppliers
$808.88/1G
50371-51-2
8 suppliers
$983.51/1G