BENZENEMETHANAMINE, ALPHA-METHYL-4-(4-MORPHOLINYL)- synthesis

Yield:728024-36-0 90%

Reaction Conditions:

Stage #1: 4-morpholinoacetophenonewith aluminium(III) triflate;(carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II);ammonia;1,2-bis-(diphenylphosphino)ethane in dodecane;toluene at -5; under 4500.45 Torr; for 0.5 h;Autoclave;
Stage #2: with hydrogen in dodecane;toluene at 140; under 30003 Torr; for 16 h;Acidic conditions;chemoselective reaction;

References:

Gallardo-Donaire, Joan;Ernst, Martin;Trapp, Oliver;Schaub, Thomas [Advanced Synthesis and Catalysis,2016,vol. 358,# 3,p. 358 - 363] Location in patent:supporting information