2,5-Thiophenedicarboxylic acid, 3,4-dibromo-, 2,5-dimethyl ester synthesis
1synthesis methods
- Product Name:2,5-Thiophenedicarboxylic acid, 3,4-dibromo-, 2,5-dimethyl ester
- CAS Number:7385-53-7
- Molecular formula:C8H6Br2O4S
- Molecular Weight:358
Yield:7385-53-7 52%
Reaction Conditions:
Stage #1: Tetrabromothiophenewith n-butyllithium in tetrahydrofuran;n-heptane at -78; for 1 h;Inert atmosphere;
Stage #2: methyl chloroformate in tetrahydrofuran;n-heptane at -78 - 20; for 16 h;Inert atmosphere;regioselective reaction;
References:
Tung, Dang Thanh;Tuan, Dang Thanh;Rasool, Nasir;Villinger, Alexander;Reinke, Helmut;Fischer, Christine;Langer, Peter [Advanced Synthesis and Catalysis,2009,vol. 351,# 10,p. 1595 - 1609] Location in patent:experimental part