2-Pyridinecarboxylic acid, 5-(phenylmethoxy)-, methyl ester synthesis

2synthesis methods

Product Name:2-Pyridinecarboxylic acid, 5-(phenylmethoxy)-, methyl ester
CAS Number:74386-59-7
Molecular formula:C14H13NO3
Molecular Weight:243.26

630120-99-9 Synthesis

630120-99-9
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67-56-1 Synthesis

67-56-1
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$9.00/25ml

201230-82-2 Synthesis

201230-82-2
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2-Pyridinecarboxylic acid, 5-(phenylmethoxy)-, methyl ester

74386-59-7
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Yield:74386-59-7 81%

Reaction Conditions:

with triethylamine;1,1'-bis-(diphenylphosphino)ferrocene;palladium diacetate at 90; for 48 h;

Steps:

2.1

Palladium acetate (0.43 g, 1.89 mmol), l,l'-bis(diphenylphosphino)ferrocene(2.10 g, 3.79 mmol), and triethylamine (11. 1 ml, 80.0 mmol) were added to a methanol solution (200 ml) of 5-(benzyloxy)-2-bromopyridine (10.0 g, 37.8 mmol) under carbon monoxide atmosphere, this mixture was stirred for 2 days at 9O⁰C. This reaction solution was cooled to room temperature, followed by concentrating this solvent under reduced pressure and purifying the obtained residue by silica gel column chromatography (Flash cartridge 65M, hexane:ethyl acetate=l :1) to obtain methyl 5-(benzyloxy)pyridin-2-carboxylate (7.48 g, yield: 81%) as an ecru solid.

References:

WO2010/24110,2010,A1 Location in patent:Page/Page column 23

59781-11-2 Synthesis

59781-11-2
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74386-59-7
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References