![](/CAS/GIF/749230-42-0.gif)
2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid synthesis
- Product Name:2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid
- CAS Number:749230-42-0
- Molecular formula:C7H3ClF2O3
- Molecular Weight:208.55
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
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$214.00/14L
![[4-chloro-3,6-difluoro-2-(methoxymethoxy)phenyl]-trimethylsilane](/CAS/20180529/GIF/749230-41-9.gif)
749230-41-9
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![2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid](/CAS/GIF/749230-42-0.gif)
749230-42-0
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$325.00/500mg
Yield:749230-42-0 65%
Reaction Conditions:
Stage #1: [4-chloro-3,6-difluoro-2-(methoxymethoxy)phenyl]trimethylsilanewith 2,2,6,6-tetramethyl-piperidine;n-butyllithium in tetrahydrofuran;hexane at -75; for 2 h;
Stage #2: carbon dioxide in tetrahydrofuran;hexane;
Stage #3: with hydrogenchloride pH=1;
References:
Marzi, Elena;Gorecka, Joanna;Schlosser, Manfred [Synthesis,2004,# 10,p. 1609 - 1618]
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2713-31-7
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![2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid](/CAS/GIF/749230-42-0.gif)
749230-42-0
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$325.00/500mg
![2,5-Difluoro-1-(methoxymethoxy)Benzene](/CAS/GIF/749230-16-8.gif)
749230-16-8
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$256.00/10g
![2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid](/CAS/GIF/749230-42-0.gif)
749230-42-0
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$325.00/500mg
![[3,6-difluoro-2-(methoxymethoxy)phenyl]-trimethylsilane](/CAS/20180601/GIF/749230-38-4.gif)
749230-38-4
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![2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid](/CAS/GIF/749230-42-0.gif)
749230-42-0
15 suppliers
$325.00/500mg