2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid synthesis

4synthesis methods

Product Name:2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid
CAS Number:749230-42-0
Molecular formula:C7H3ClF2O3
Molecular Weight:208.55

124-38-9
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$214.00/14L

[4-chloro-3,6-difluoro-2-(methoxymethoxy)phenyl]-trimethylsilane

749230-41-9
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2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid

749230-42-0
15 suppliers
$325.00/500mg

Yield:749230-42-0 65%

Reaction Conditions:

Stage #1: [4-chloro-3,6-difluoro-2-(methoxymethoxy)phenyl]trimethylsilanewith 2,2,6,6-tetramethyl-piperidine;n-butyllithium in tetrahydrofuran;hexane at -75; for 2 h;
Stage #2: carbon dioxide in tetrahydrofuran;hexane;
Stage #3: with hydrogenchloride pH=1;

References:

Marzi, Elena;Gorecka, Joanna;Schlosser, Manfred [Synthesis,2004,# 10,p. 1609 - 1618]

2713-31-7 Synthesis

2713-31-7
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$5.00/1g

749230-42-0
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$325.00/500mg

References

749230-16-8 Synthesis

749230-16-8
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$256.00/10g

749230-42-0
15 suppliers
$325.00/500mg

References

[3,6-difluoro-2-(methoxymethoxy)phenyl]-trimethylsilane

749230-38-4
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inquiry

749230-42-0
15 suppliers
$325.00/500mg

References