ChemicalBook CAS DataBase List 5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid synthesis

7synthesis methods

Product Name:5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid
CAS Number:74936-72-4
Molecular formula:C16H16N2O6
Molecular Weight:332.31

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-(2-Cyanoethyl) 5-Methyl Ester

75130-24-4
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5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

74936-72-4
254 suppliers
$15.00/5g

Yield:74936-72-4 86.8%

Reaction Conditions:

with water;sodium hydroxide at 20;Reagent/catalyst;

Steps:

1.3; 2.3

(3) Intermediate 2 (1800g),750 g of a 3% aqueous sodium hydroxide solution was added to the reaction.The reaction is carried out at room temperature for 2 to 3 hours; and then extracted with 10000 g of dichloromethane;The aqueous phase was acidified to pH = 1-2 with 10% hydrochloric acid. Filtered, dried,It has a pale yellow solid. The obtained solid was recrystallized from methanol to give Intermediate 3 (1346 g).The yield was 86.8%.

References:

CN109111431,2019,A Location in patent:Paragraph 0042; 0046; 0056; 0060

21881-77-6 Synthesis