tert-Butyl (1-(2-aminoethyl)cyclopropyl)carbamate synthesis

Yield:-

Reaction Conditions:

with hydrazine in ethanol; for 16 h;Heating / reflux;

Steps:

1.5 1.5 Tert-butyl 1-(2-aminoethyl)cyclopropylcarbamate

To a solution of 4.57g (13.83 mmol) of tert-butyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]cyclopropylcarbamate in 80 ml of ethanol was added 3.36ml (69.16 mmol) of hydrazine hydrate and the resulting mixture was heated under reflux for 16h. The mixture was filtered and washed with diethyl ether. The filtrate was evaporated to dryness to give 2.3g of pure compound as an orange oil.

References:

EP1454909,2004,A1 Location in patent:Page 10