1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride synthesis
1synthesis methods
- Product Name:1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride
- CAS Number:753499-14-8
- Molecular formula:C19H19F3N2O2
- Molecular Weight:400.83
Yield:753499-14-8 1.02 g
Reaction Conditions:
Stage #1: (1,4-diazabicyclo[3.2.2]nonan-4-yl)(5-bromofuran-2-yl)methanone;(meta-(trifluoromethyl)phenyl)boronic acidwith tetrakis(triphenylphosphine) palladium(0);sodium carbonate in 1,4-dioxane at 85; for 2 h;Inert atmosphere;
Stage #2: with hydrogenchloride in 1,4-dioxane;
References:
Gaidhani, Nikhil;Tucci, Fabio C.;Kem, William R.;Beaton, Graham;Uteshev, Victor V. [British Journal of Pharmacology,2021,vol. 178,# 7,p. 1684 - 1704]