ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE synthesis

Yield:-

Reaction Conditions:

with tetrabutylammonium bromide in lithium hydroxide monohydrate at 30 - 50;

Steps:

1.a; 2.a; 3.a (A) cyclization reaction

1. Prepare a solution of material a: put 1897g of water and 165g of thiourea (2.17mol) into the configuration tank, control the stirring temperature at 30-50°C, dissolve the solid into an 8% thiourea aqueous solution, and then add 3.3g of tetrabutyl After stirring and dissolving, the ammonium bromide is placed at a low temperature and placed in the raw material tank A (the bottom of the raw material tank is connected with the corresponding feeding pipeline of the microchannel through a valve) for use.2. Preparation of material b solution: take 340g of ethyl 4-chloroacetoacetate (2.07mol) (density 1.218g/ml), place it in raw material tank B (the bottom of this raw material tank is connected to the corresponding feed pipe of the microchannel through a valve) )stand-by.3. Open the valve at the bottom of the raw material tank, and transport the solution of material a in the raw material tank A and the solution of material b in the raw material tank B respectively through the digital display syringe pump, and set the flow rate of the raw material tank A to 38.0ml/min and the flow rate of the raw material tank B to 5.58 through the metering pump. ml/min, the two materials were simultaneously transported to the first section of the microchannel reactor by the feed pump according to the set flow rate, and the reaction was held in the channel for 100s. The temperature is 37°C, and the reacted material is passed into the pipeline into the second section of the microchannel reactor.

References:

CN114853691,2022,A Location in patent:Paragraph 0032-0035; 0041-0044; 0050-0053