7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine synthesis
- Product Name:7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
- CAS Number:768350-54-5
- Molecular formula:C22H17BrFN3O2
- Molecular Weight:454.29
367-24-8
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$15.00/25g
162364-72-9
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$8.00/250mg
768350-54-5
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$111.00/100mg
Yield:768350-54-5 93%
Reaction Conditions:
with hydrogenchloride in isopropyl alcohol; for 2 h;Reflux;
Steps:
7-(Benzyloxy)-N-(4-chloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride (2a)
Hydrogen chloride (6.5 M, 2.54 mL) was added to a mixture of compound 1 (4.51 g, 15.0 mmol) and 4-chloro-2-fluoroaniline (2.40 g, 16.5 mmol) in 2-propanol (160 mL), then the mixture was heated at reflux for 2 h. The mixture was cooled and solid was filtered. The solid was then washed with 2-propanol, followed by Et2O, and dried under vacuum overnight to give 2a (7.9 g, 94%) as a white solid.
References:
Gao, Mingzhang;Lola, Christian M.;Wang, Min;Miller, Kathy D.;Sledge, George W.;Zheng, Qi-Huang [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 11,p. 3222 - 3226] Location in patent:experimental part
179688-01-8
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768350-54-5
45 suppliers
$111.00/100mg
60547-98-0
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inquiry
768350-54-5
45 suppliers
$111.00/100mg
179688-01-8
164 suppliers
$19.00/500mg
768350-54-5
45 suppliers
$111.00/100mg
60547-92-4
87 suppliers
$6.00/250mg
768350-54-5
45 suppliers
$111.00/100mg