ChemicalBook CAS DataBase List 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER synthesis

3synthesis methods

Product Name:4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER
CAS Number:778646-95-0
Molecular formula:C12H22N2O4
Molecular Weight:258.31

1095173-08-2
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4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

778646-95-0
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Yield:778646-95-0 96%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol at 20; under 2585.81 Torr; for 20 h;

Steps:

1

(2R,4R)-1-tert-butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate (2R,4R)-1-tert-butyl 2-methyl 4-azidopiperidine-1,2-dicarboxylate (22.5 g, 79 mmol) was dissolved in methanol (400 mL), Pd/C (10%, 6 g) was added, and the apparatus was flushed three times with N₂ and H₂. The reaction mixture was hydrogenated at a pressure of 50 psi at room temperature for 20 hours, filtered through Celite and rinsed with methanol and then concentrated under reduced pressure to give the amine as a colorless oil 20 g (96%). GC-MS: 258 (t=2.8 min).

References:

US2009/5416,2009,A1 Location in patent:Page/Page column 43

405229-64-3
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778646-95-0
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References

321744-26-7 Synthesis

(2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER

321744-26-7
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$206.00/100mg

778646-95-0
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References