(S)-3-(tert-butyl(2-(2,4-difluorophenyl)-2-hydroxyethyl)amino)propanenitrile synthesis

3synthesis methods

Product Name:(S)-3-(tert-butyl(2-(2,4-difluorophenyl)-2-hydroxyethyl)amino)propanenitrile
CAS Number:782482-51-3
Molecular formula:C15H20F2N2O
Molecular Weight:282.33

(S)-2-(TERT-BUTYLAMINO)-1-(2,4-DIFLUOROPHENYL)ETHANOL

782482-50-2
11 suppliers
$356.00/1g

107-13-1 Synthesis

107-13-1
409 suppliers
$17.00/25ML

(S)-3-(tert-butyl(2-(2,4-difluorophenyl)-2-hydroxyethyl)amino)propanenitrile

782482-51-3
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Yield:782482-51-3 92%

Reaction Conditions:

Stage #1: (1S)-2-(tert-butylamino)-1-(2,4-difluorophenyl)ethanol;acrylonitrile for 22 h;Heating;
Stage #2: with ethanol;formamide for 15 h;Heating;

References:

Chung, John Y. L.;Cvetovich, Raymond;Amato, Joseph;McWilliams, J. Christopher;Reamer, Robert;DiMichele, Lisa [Journal of Organic Chemistry,2005,vol. 70,# 9,p. 3592 - 3601]

51336-94-8 Synthesis

51336-94-8
320 suppliers
$6.00/5g

782482-51-3
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References

(1S)-2-CHLORO-1-(2,4-DIFLUOROPHENYL)ETHANOL

330156-49-5
29 suppliers
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782482-51-3
17 suppliers
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References