Glycine, N-phenyl-, methyl ester, hydrochloride (1:1) synthesis
- Product Name:Glycine, N-phenyl-, methyl ester, hydrochloride (1:1)
- CAS Number:78733-46-7
- Molecular formula:C9H12ClNO2
- Molecular Weight:201.65
103-01-5
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Yield:78733-46-7 100%
Reaction Conditions:
with thionyl chloride in methanol;
Steps:
3.a a)
a) D-Phenylglycine methyl ester hydrochloride (12) To a stirred solution of D-phenylglycine (11) (20 g, 132 mmol) in methanol (100 ml) at -10° C. was added thionyl chloride (10.62 ml, 146 mmol) and the solution was refluxed for 2 hours. After concentration in vacuo the product was recrystallized from methanol-diethyl ether mixture to give the title compound (12) (26.6 g, 100%); δH (D2 O; 200 MHz) 2.95-3.18 (2H, m, CH2 CH), 3.62 (3H, s, CH3), 4.21 (1H, dd, J=6.1 and 7.4, CH2 CH), 4.59 (2H, s, NH2), 7.06-7.27 (5H, m, ArCH).
References:
US5801249,1998,A
