7-BROMO-4-METHYL-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE synthesis

4synthesis methods

Product Name:7-BROMO-4-METHYL-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE
CAS Number:78756-36-2
Molecular formula:C10H9BrN2O2
Molecular Weight:269.09

4-METHYL-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE

3415-35-8
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$35.00/200μmol

7-BROMO-4-METHYL-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE

78756-36-2
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Yield:78756-36-2 75%

Reaction Conditions:

with bromine;sodium acetate;acetic acid at 20; for 24 h;

Steps:

2 Step 2:

Step 2:
Preparation of 7-Bromo-4-methyl-1H-1,4-benzodiazepin-2,5-diaone (4)
To a solution of 1.53 g (8.04 mmol) of 4-methyl-1H-1,4-benzodiazepin-2,5-diaone(3) in 20 mL of acetic acid were slowly added 1.65 g (20.1 mmol) of sodium acetate and 1.03 g (20.1 mmol) of bromine (Br₂), followed by stirring the reaction mixture at room temperature for 24 hrs.
Then, the reaction mixture was poured to 200 mL of ice water and filtered.
Purification by flash column chromatography (5% methanol/dichloromethane) afforded 1.58 g of 7-bromo-4-methyl-1H-1,4-benzodiazepin-2,5-diaone (4) as a white solid (75%) (¹H NMR (400 MHz, CDCl₃) δ 3.29 (s, 3H), 3.90 (s, 2H), 6.91 (d, J=8.4 Hz, 1H), 7.57 (dd, J=8.4, 2.4 Hz, 1H), 8.09 (d, J=2.4 Hz, 1H), 8.77 (s, 1H)).

References:

US2014/81018,2014,A1 Location in patent:Paragraph 0032; 0055; 0056

4692-98-2 Synthesis