4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-6-OXO-, ETHYL ESTER synthesis
- Product Name:4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-6-OXO-, ETHYL ESTER
- CAS Number:79089-72-8
- Molecular formula:C14H12FN3O3
- Molecular Weight:289.26
320-98-9
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Yield:-
Steps:
Multi-step reaction with 6 steps
1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h
1.2: 16 h / 20 °C / Inert atmosphere
2.1: acetic acid; zinc / water; tetrahydrofuran; methanol / 20 h / 70 °C
3.1: triethylamine / dichloromethane / 72 h / Inert atmosphere; Cooling with ice
4.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 50 °C
5.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 °C
5.2: 3 h / -20 - 20 °C
5.3: -78 - 20 °C
6.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C
References:
WO2015/95783,2015,A1
2999-46-4
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