4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzonitrile synthesis
- Product Name:4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzonitrile
- CAS Number:79421-39-9
- Molecular formula:C14H16N2O2
- Molecular Weight:244.29
Yield:79421-39-9 98%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide at 120; for 16 h;
Steps:
4.5. General procedure for synthesis of compounds 7a-c
General procedure: To a solution of 6 (2 g,14.2mmol) in DMSO (10 mL), K2CO3 (2.49 g, 18.05 mmol) and the corresponding aryl fluoride (12.9 mmol) were added, and the reaction mixture was stirred at 120 °C for 16 h. The mixture was cooled to room temperature, poured into water (50mL), and the yellow precipitate was filtered off.
References:
Hrast, Martina;Turk, Samo;Sosi?, Izidor;Knez, Damijan;Randall, Christopher P.;Barreteau, Hélène;Contreras-Martel, Carlos;Dessen, Andréa;O'Neill, Alex J.;Mengin-Lecreulx, Dominique;Blanot, Didier;Gobec, Stanislav [European Journal of Medicinal Chemistry,2013,vol. 66,p. 32 - 45]
1194-02-1
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584-08-7
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![1,4-Dioxa-8-azaspiro[4.5]decane](/CAS/GIF/177-11-7.gif)
177-11-7
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79421-39-9
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