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(2R,5R)-5-Hydroxy-1,2-piperidinedicarboxylic acid 2-methyl 1-benzyl ester synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 7 steps
1: 94 percent / NaHCO3
2: 82 percent / TsOH / benzene / Heating
3: 93 percent / NaOMe
4: Et3N / tetrahydrofuran
5: diethyl ether
6: 52 percent / [Rh(OAc)2]2 / benzene / Heating
7: 93 percent / NaBH4 / methanol

References:

Shirude, Pravin S.;Kumar, Vaijayanti A.;Ganesh, Krishna N. [Tetrahedron,2004,vol. 60,# 42,p. 9485 - 9491]