8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one synthesis
- Product Name:8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one
- CAS Number:37949-03-4
- Molecular formula:C11H12O
- Molecular Weight:160.21
24790-66-7
2 suppliers
inquiry
37949-03-4
87 suppliers
$27.00/100mg
Yield:37949-03-4 84%
Reaction Conditions:
Stage #1: dimethyl 7-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulene-6,8-dicarboxylatewith sulfuric acid in water;acetonitrile;Inert atmosphere;
Stage #2: with sodium hydroxide in diethyl ether;water;acetonitrile;
Steps:
3
Preparation 3 5,6,8,9-tetrahydro-benzocyclohepten-7-one (compound having the formula II) The isomeric mixture of dimethyl 7-oxo-5,6,8,9-tetrahydrobenzocycloheptene-6,8-dicarboxylate (80 g) obtained according to preparation 2 is refluxed in a 3M aqueous sulphuric acid (300 mL) and acetonitrile (50 mL) solution overnight under argon. The mixture is diluted with diethyl ether, neutralized with a 2M aqueous sodium hydroxide solution (3*300 mL), dried on magnesium sulphate and evaporated to dryness. The residue is distilled off at 97-98° C. under 0.4-0.5 Torr to obtain colourless crystals (26.1 g, 84% from α,α'-dibromo-o-xylene). Melting point: 43-44° C. 1H-NMR (CDCl3): 7.23 (m, 4 Har); 2.91 (m, 2H-C(6), 2H-C(8)); 2.62 (m, 2H-C(5), 2H-C(9)).
References:
US2010/69504,2010,A1 Location in patent:Page/Page column 5
56613-15-1
0 suppliers
inquiry
37949-03-4
87 suppliers
$27.00/100mg
4443-91-8
5 suppliers
inquiry
37949-03-4
87 suppliers
$27.00/100mg
5200-96-4
3 suppliers
inquiry
37949-03-4
87 suppliers
$27.00/100mg
33188-51-1
0 suppliers
inquiry
37949-03-4
87 suppliers
$27.00/100mg