ChemicalBook CAS DataBase List 8-Azabicyclo[3.2.1]octan-3-ol

8-Azabicyclo[3.2.1]octan-3-ol synthesis

2synthesis methods

Product Name:8-Azabicyclo[3.2.1]octan-3-ol
CAS Number:7432-11-3
Molecular formula:C7H13NO
Molecular Weight:127.18

478837-18-2 Synthesis

tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

478837-18-2
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7432-11-3
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Yield:7432-11-3 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;water at 25; for 12 h;

Steps:

51.1 Step 1: Preparation of 8-azabicyclo[3.2.1]octan-3-ol

A solution of tert-butyl 3-hydroxy-8-azabicyclo[3.2. 1]octane-8-carboxylate (322 mg, 1.41 mmol) in dioxane (4 M HC1 solution in Dioxane, 3 mL, 12 mmol) was stirred at 25 °C for 12hours. After the reaction was completed, the mixture was concentrated in vacuo to give 8-azabicyclo[3.2.1]octan-3-ol (180 mg, quant.) as a white solid. MS obsd. (ESI) [(M+H)]: 128.1.

References:

WO2020/79106,2020,A1 Location in patent:Page/Page column 95; 96

5632-84-8
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References