8-bromodibenzo[b,d]furan-2-carbonitrile synthesis
- Product Name:8-bromodibenzo[b,d]furan-2-carbonitrile
- CAS Number:1442648-14-7
- Molecular formula:C13H6BrNO
- Molecular Weight:272.1
20927-96-2
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Yield:1442648-14-7 73%
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide at 50 - 100; for 2 h;
Steps:
13
Synthesis of intermediate 2-61-4:26.2 g of the intermediate 2-61-3 was dissolved in 150 ml of N,N-dimethylformamide,The temperature was raised to 50 ° C, and 18.7 g of NBS dissolved in 200 ml of N,N-dimethylformamide was added dropwise, and the mixture was heated to 100 ° C for 2 h, and the reaction of the starting materials was completed.After the reaction solution was cooled to room temperature, water was added dropwise and stirred for 20 min.Drying gave 26 g of Intermediate 2-61-4 (yield: 73%).
References:
CN108727424,2018,A Location in patent:Paragraph 0193; 0194; 0199
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