![](/CAS/GIF/861396-95-4.gif)
8-Chloro-2-ethoxyquinolin-4-ol synthesis
- Product Name:8-Chloro-2-ethoxyquinolin-4-ol
- CAS Number:861396-95-4
- Molecular formula:C11H10ClNO2
- Molecular Weight:223.66
![Propanoic acid, 3-[(2-chlorophenyl)imino]-3-ethoxy-, ethyl ester, (3Z)-](/CAS/20210305/GIF/872496-77-0.gif)
872496-77-0
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![8-Chloro-2-ethoxyquinolin-4-ol](/CAS/GIF/861396-95-4.gif)
861396-95-4
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Yield:861396-95-4 53%
Reaction Conditions:
in diphenylether at 240 - 250; for 0.133333 h;
Steps:
1G.C
Step C:; The condensation product 1g4 (1.73 g, 6.41 mmol) was dissolved in diphenylether (10 ml) and placed in a sand bath (300°C). The internal temperature wasmonitored and allowed to stay between 240-250°C for 8 minutes. The mixture wascooled and then directly loaded on a silica gel column and eluted first with hexanes,then with 30% EtOAc/Hexanes and finally 50% EtOAc/hexanes. The product wasconcentrated and dried in vacuo to give the corresponding 4-hydroxyquinolinederivative 1g5 as a beige crystalline solid (0.76 g, 53%). MS electrospray: (M + H)+;224 and (M - H)'; 222.
References:
WO2006/7700,2006,A1 Location in patent:Page/Page column 67