![](/CAS/GIF/911389-21-4.gif)
8-Chloro-2-Methyl-1,5-naphthyridine synthesis
- Product Name:8-Chloro-2-Methyl-1,5-naphthyridine
- CAS Number:911389-21-4
- Molecular formula:C9H7ClN2
- Molecular Weight:178.62
![4-Hydroxy-6-methyl-1,5-naphthyridine](/CAS2/GIF/23443-24-5.gif)
23443-24-5
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![8-Chloro-2-Methyl-1,5-naphthyridine](/CAS/GIF/911389-21-4.gif)
911389-21-4
23 suppliers
$240.00/100mg
Yield: 67%
Reaction Conditions:
Stage #1:6-methyl-[1,5]naphthyridin-4-ol with trichlorophosphate for 2 h;Heating / reflux;
Stage #2: with ammonia in water
Steps:
20
8-Chloro-2-methyl-[1,5]naphthyridine; The suspension of 6-methyl-[1,5]naphthyridin-4-ol (1.60 g, 9.99 mmol) in POCl3 (25 mL) was heated under refluxing for 2 hrs. After cooling to room temperature, the reaction mixture was quenched with ice water and basified with NH4OH followed by extraction with AcOEt. The organic layer was washed with brine and dried over NaSO4, and concentrated to give 8-chloro-2-methyl-[1,5]naphthyridine as a brown solid (1.2 g, 67%). HR-MS-EI (+) m/e calcd for C9H7N2Cl (M+) 178.0298, found 178.0297.
References:
Location in patent:Page/Page column 9; 19