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8-chloro-3-iodo-2-MethyliMidazo[1,2-a]pyrazine synthesis
- Product Name:8-chloro-3-iodo-2-MethyliMidazo[1,2-a]pyrazine
- CAS Number:1334167-35-9
- Molecular formula:C7H5ClIN3
- Molecular Weight:293.49
![8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE](/CAS/GIF/85333-43-3.gif)
85333-43-3
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1334167-35-9
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Yield:1334167-35-9 97%
Reaction Conditions:
with N-iodo-succinimide;acetic acid in dichloromethane at 0 - 20; for 16 h;
Steps:
A25
N-Iodosuccinimide (14.1 g, 62 mmol) was added to a stirred solution of intermediate 4 (9.58 g, 57 mmol) in a mixture of DCM and acetic acid at 0 °C. The mixture was allowed to warm to RT and then stirred for 16 h. The mixture was diluted with further DCM and washed with a saturated solution of sodium carbonate and sodium thiosulfite. The organic layer was separated, dried (Na2S04), filtered and the solvents evaporated in vacuo. The crude product was precipitated from diisopropyl ether to yieldintermediate 25 (16 g, 97%) as a pale brown solid which was used in the next step without further purification.
References:
WO2011/110545,2011,A1 Location in patent:Page/Page column 80