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ChemicalBook CAS DataBase List 8-(tert-Butoxy)-8-oxooctanoic acid
234081-94-8

8-(tert-Butoxy)-8-oxooctanoic acid synthesis

4synthesis methods
-

Yield: 31%

Reaction Conditions:

with dmap;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane at 20; for 5 h;

Steps:

25 Preparation 25: 8-(ferf-Butoxy)-8-oxooctanoic acid
Octanedioic acid (1.00 g, 5.75 mmol), 2-methyl-2-propanol (6.9 mL, 71.8 mmol), EDCI (1.1 g, 5.74 mmol) and DMAP (0.7 g, 5.74 mmol) were dissolved in DCM (6.8 mL). The reaction was stirred at room temperature for 5 hours. The reaction mixture was diluted with diethyl ether (60 mL) and washed with 0.01 N HCI (50 mL) and water (50 mL). The organic phase was then dried over MgS04 and the solvent was removed in vacuo. The crude product was purified by flash column chromatography with 1 : 1 EtOAc: Petrol to give 8-(fe f-butoxy)-8- oxooctanoic acid (0.41 g, 1.77 mmol, 31%) as colourless oil. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.94 (br s, 1 H), 2.18 (dd, J = 14.6, 7.3 Hz, 4H), 1.54-1.42 (m, 4H), 1.40 (s, 9H), 1.34-1.20 (m, 4H)

References:

OTSUKA PHARMACEUTICAL CO., LTD.;HEIGHTMAN, Thomas, Daniel;LEBRAUD, Honorine WO2017/212329, 2017, A1 Location in patent:Page/Page column 30; 83; 84