8-tert-butylchroman-4-one synthesis

3synthesis methods

Product Name:8-tert-butylchroman-4-one
CAS Number:23067-79-0
Molecular formula:C13H16O2
Molecular Weight:204.26

Benzene, 1-[(3-chloro-2-propyn-1-yl)oxy]-2-(1,1-dimethylethyl)-

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23067-79-0
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Yield:23067-79-0 44%

Reaction Conditions:

in ethylene glycol; for 4 h;Reflux;

Steps:

4.3

Step 3: 8-(tert-Butyl)chroman-4-one (4c) The solution of compound 4b (0.5 g, 2.3 mmol) in anhydrous ethylene glycol (5 mL) was heated to reflux for 4 h. The reaction mixture was cooled, poured into water and extracted with Et₂O twice. The organic layers were combined, washed with 1N sodium hydroxide and sat. ammonium carbonate sequentially, dried over Na₂SO₄, filtered and concentrated under reduced pressure. The residue was purified by CC (elute: PE) to give compound 4c (0.2 g, 44%) as an oil.

References:

EP2511263,2012,A1 Location in patent:Page/Page column 26

Benzene, 1-(1,1-dimethylethyl)-2-(2-propyn-1-yloxy)-

55619-88-0
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23067-79-0
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References

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$16.00/25mL

23067-79-0
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References