1-CHLORO-9,10-DIHYDRO-9-OXO-4-ACRIDINECARBOXYLIC ACID synthesis

8synthesis methods

Product Name:1-CHLORO-9,10-DIHYDRO-9-OXO-4-ACRIDINECARBOXYLIC ACID
CAS Number:80258-99-7
Molecular formula:C14H8ClNO3
Molecular Weight:273.67

63329-53-3 Synthesis

63329-53-3
43 suppliers
inquiry

1-CHLORO-9,10-DIHYDRO-9-OXO-4-ACRIDINECARBOXYLIC ACID

80258-99-7
8 suppliers
inquiry

Yield:80258-99-7 35%

Reaction Conditions:

with sulfuric acid at 80; for 5 h;Friedel-Crafts Acylation;

Steps:

3.2. General procedure for compounds 4a-e.

General procedure: Compound 3a-e (1.19 mmol) was dissolved in concentrated sulfuric acid (10 mL) and heated to 80 °C for 5 h. The reaction was added onto ice (50 mL) dropwise and then buffered to pH 5 with NaOH (a.q.). The resulting suspension was stirred for 30 minutes, and the precipitate was filtered and washed with water and then dried to give solid powder 4a-e.

References:

Zhang, Bin;Chen, Kang;Wang, Ning;Gao, Chunmei;Sun, Qinsheng;Li, Lulu;Chen, Yuzong;Tan, Chunyan;Liu, Hongxia;Jiang, Yuyang [European Journal of Medicinal Chemistry,2015,vol. 93,p. 214 - 226] Location in patent:supporting information

63329-53-3 Synthesis

63329-53-3
43 suppliers
inquiry