ChemicalBook CAS DataBase List 1-NaphthaleneMethanaMine, 7,8-dihydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-

1-NaphthaleneMethanaMine, 7,8-dihydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]- synthesis

12synthesis methods

Product Name:1-NaphthaleneMethanaMine, 7,8-dihydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-
CAS Number:802918-46-3
Molecular formula:C22H24F3N
Molecular Weight:359.4279

3-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPENOYLHLORIDE

60689-14-7
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1-NaphthaleneMethanaMine, 7,8-dihydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-

802918-46-3
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Yield:-

Steps:

Multi-step reaction with 5 steps
1: 92 percent / NH₄OH / dioxane / 0 °C
2: 89 percent / H₂ / Pd/C / methanol / 16 h / 20 °C
3: 65 percent / LAH / tetrahydrofuran / 4 h / Heating
4: Ti(OiPr)4
5: NaBH₄ / methanol

References:

Wang, Xin;Chen, Ying;Crockett, Richard;Briones, Jorge;Yan, Tony;Orihuela, Carlos;Zhi, Benxin;Ng, John [Tetrahedron Letters,2004,vol. 45,# 45,p. 8355 - 8358]