Pyrido[2,3-b]pyrazine-2,3-dione, 1,4-dihydro-4-methyl- (9CI) synthesis

7synthesis methods

Product Name:Pyrido[2,3-b]pyrazine-2,3-dione, 1,4-dihydro-4-methyl- (9CI)
CAS Number:80708-25-4
Molecular formula:C8H7N3O2
Molecular Weight:177.16

5028-20-6 Synthesis

5028-20-6
62 suppliers
$34.00/100mg

144-62-7 Synthesis

144-62-7
744 suppliers
$5.00/5g

Pyrido[2,3-b]pyrazine-2,3-dione, 1,4-dihydro-4-methyl- (9CI)

80708-25-4
13 suppliers
$680.00/100mg

Yield:80708-25-4 30.03%

Reaction Conditions:

with hydrogenchloride in water at 20 - 110; for 3 h;

Steps:

1.C Step C: Preparation of 4-methyl-1,4-dihydropyrido [2,3-b] piperazine-2,3-dione

0.8 g (3.6 mmol) of N-methyl-2,3-diaminopyridine, 0.9 mL of hydrochloric acid and 1 mL of water were added to a single-At room temperature, 0.5 g of oxalic acid was added slowly. After refluxing, reflux at 110 ° C for 3 h. Allow to cool to room temperature, suction, dry,To give 0.3 g of a pale green solid product (yield 30.03%).

References:

CN106831776,2017,A Location in patent:Paragraph 0103; 0104; 0105