2-METHYL-6-NITRO-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis

Yield:81438-60-0 65%

Reaction Conditions:

in ethanol at 120; for 0.333333 h;Microwave irradiation;

Steps:

Typical procedure for thesynthesis of 3a

General procedure: A 35-mL microwave process vial was charged with 1a (1.08 g,10 mmol), 2a (1.64 g, 10 mmol) and EtOH (20 mL). The reaction mixture was stirred for 20 min at 120 °C. After cooling to room temperature, the mixture was poured into cold water (100 mL) and stirred for another 1 h. The precipitate was filtered out and dried in vacuum to give the title compound 3a (1.64 g,75%). For 7-11, 13, 18, 19, 22 and 24, after the reaction completed, the mixture was concentrated to dryness under reduced pressure and the residue was purified by silica gel column chromatography (eluted with petroleum ether : EtOAc = 4:1) to get the corresponding title compounds.

References:

Li, Lin-Hu;Wu, Zhao-Yang;Li, Zhuo-Rong;Liu, Ming-Liang;Guo, Hui-Yuan;Zhang, Qiu-Rong [Heterocycles,2015,vol. 91,# 11,p. 2087 - 2096]