Labetalol Hydrochloride Impurity 19（(R,S)-Labetalol Hydrochloride） synthesis

6synthesis methods

Product Name:Labetalol Hydrochloride Impurity 19（(R,S)-Labetalol Hydrochloride）
CAS Number:81602-14-4
Molecular formula:C19H25ClN2O3
Molecular Weight:364.87

2550-26-7
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Labetalol Hydrochloride Impurity 19（(R,S)-Labetalol Hydrochloride）

81602-14-4
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: p-TsOH*H₂O / benzene / 14 h / Heating
2: NaBH₄ / methanol / 16 h / Ambient temperature
4: K₂CO₃ / dimethylformamide / 4 h / Ambient temperature
5: LiBH₄ / benzene; tetrahydrofuran / 2 h / 0 °C
6: H₂, 1 N aq. HCl / 20percent Pd(OH)2/C / ethanol / 2 h / 2280 Torr / Ambient temperature

References:

Gold, Elijah H.;Chang, Wei;Cohen, Marvin;Baum, Thomas;Ehrreich, Steward;et al. [Journal of Medicinal Chemistry,1982,vol. 25,# 11,p. 1363 - 1370]

68164-04-5 Synthesis