2-TRIFLUOROMETHYL-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID synthesis
- Product Name:2-TRIFLUOROMETHYL-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID
- CAS Number:82791-93-3
- Molecular formula:C9H5F3N2O2
- Molecular Weight:230.14
619-05-6
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$19.00/25g
82791-93-3
29 suppliers
$90.00/500mg
Yield:82791-93-3 86%
Reaction Conditions:
with trifluoroacetic acid at 70; for 16 h;
Steps:
xxxviii 2-(Trifluoromethyl)-1 H-benzoicilimidazole-6-carboxylic acid 1106
A solution of 3,4-diaminobenzoic acid (1 .0 g, 6.6 mmol) in TFA (15 mL) was stirred at 70 °C for 16 hours. The reaction mixture was concentrated, the crude material was purified by column chromatography (DCM: methanol=50:1 ) to give the title compound as an off-white solid (1 .3 g, 86%). LCMS-C: RT 1 .76 min; m/z 231 .1 [M+H]
References:
WO2016/34673,2016,A1 Location in patent:Page/Page column 114
76-05-1
680 suppliers
$9.00/1g
619-05-6
284 suppliers
$19.00/25g
82791-93-3
29 suppliers
$90.00/500mg