5-Bromo-2-methylpyrimidine-4-carboxylic acid ethyl ester synthesis
- Product Name:5-Bromo-2-methylpyrimidine-4-carboxylic acid ethyl ester
- CAS Number:83410-38-2
- Molecular formula:C8H9BrN2O2
- Molecular Weight:245.07
Yield:83410-38-2 52%
Reaction Conditions:
Stage #1: 5-bromo-2-methylpyrimidinewith ferrous(II) sulfate heptahydrate;sulfuric acid in water;toluene at -10;Minisci reaction;
Stage #2: α-hydroxy-α-(ethoxycarbonyl)ethyl hydroperoxidewith acetic acid in water;toluene at -10 - 0; for 1.5 h;Minisci reaction;
Stage #3: with sodium hydroxide in water;toluene; pH=7;Cooling with ice;regioselective reaction;
References:
Regan, Collin F.;Pierre, Fabrice;Schwaebe, Michael K.;Haddach, Mustapha;Jung, Michael E.;Ryckman, David M. [Synlett,2012,# 3,p. 443 - 447] Location in patent:experimental part
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