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834884-60-5

(R)-Methyl-(5,6,7,8-tetrahydro-quinolin-8-yl)-amine synthesis

2synthesis methods
6165-69-1 Synthesis
3-Thiopheneboronic acid

6165-69-1
338 suppliers
$12.72/1gm:

149806-06-4 Synthesis
2-Bromopyridine-5-carbaldehyde

149806-06-4
411 suppliers
$5.00/1g

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Yield:834884-60-5 65%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium(0);sodium carbonate in ethanol;water;toluene; for 4 h;Inert atmosphere;Reflux;Suzuki Coupling;

References:

Emmerich, Juliette;Hu, Qingzhong;Hanke, Nina;Hartmann, Rolf W. [Journal of Medicinal Chemistry,2013,vol. 56,# 15,p. 6022 - 6032] Location in patent:supporting information