![](/CAS/GIF/83622-42-8.gif)
2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane synthesis
- Product Name:2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- CAS Number:83622-42-8
- Molecular formula:C7H14BClO2
- Molecular Weight:176.45
![Pinacol](/CAS/GIF/76-09-5.gif)
76-09-5
377 suppliers
$8.19/250mg
![2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane](/CAS/GIF/83622-42-8.gif)
83622-42-8
78 suppliers
$55.00/250mg
Yield: 81%
Reaction Conditions:
Stage #1:Chloroiodomethane with n-butyllithium;Triisopropyl borate in tetrahydrofuran;hexane at -78 - 20; for 2.83333 h;
Stage #2:2,3-dimethyl-2,3-butane diol with hydrogenchloride in tetrahydrofuran;hexane;ethyl acetate at 0 - 20; for 0.666667 h;
Steps:
1
To the mixture of triisopropyl borate (15 ml, 65 mmol), chloroiodomethane (13 g, 72 mmol), and tetrahydrofuran (78 ml), n-butyllithium (a 1.6 M n-hexane solution, 41 ml, 65 mmol) was added dropwise at -78° C. (an outer temperature) for 20 min. and then the obtained mixture was stirred at room temperature for 2.5 hours. The reaction mixture was cooled to 0° C. (an outer temperature), and a 4 N hydrochloric acid-ethyl acetate solution was added dropwise thereto at the same temperature until the reaction mixture became neutral. At the same temperature, pinacol (7.7 g, 65 mmol) was added to the reaction mixture, and then the reaction mixture was stirred at room temperature for 40 min. The solvents were evaporated under reduced pressure, and then the obtained residue was distilled under reduced pressure (63-70° C., 11 mmHg), thereby obtaining the entitled compound (9.2 g, 52 mmol, 81%). 1H-NMR Spectrum (CDCl3) δ(ppm): 1.30(12H, s), 2.97(2H, s)
References:
Eisai R&D Management Co., Ltd. US2008/15351, 2008, A1 Location in patent:Page/Page column 11
![Pinacol](/CAS/GIF/76-09-5.gif)
76-09-5
377 suppliers
$8.19/250mg
![Triisopropyl borate](/CAS/GIF/5419-55-6.gif)
5419-55-6
370 suppliers
$12.00/5g
![Chloroiodomethane](/CAS/GIF/593-71-5.gif)
593-71-5
296 suppliers
$6.00/5g
![2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane](/CAS/GIF/83622-42-8.gif)
83622-42-8
78 suppliers
$55.00/250mg
![Chloroiodomethane](/CAS/GIF/593-71-5.gif)
593-71-5
296 suppliers
$6.00/5g
![2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane](/CAS/GIF/61676-62-8.gif)
61676-62-8
311 suppliers
$10.00/5g
![2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane](/CAS/GIF/83622-42-8.gif)
83622-42-8
78 suppliers
$55.00/250mg
![Pinacol](/CAS/GIF/76-09-5.gif)
76-09-5
377 suppliers
$8.19/250mg
![Chloroiodomethane](/CAS/GIF/593-71-5.gif)
593-71-5
296 suppliers
$6.00/5g
![2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane](/CAS/GIF/83622-42-8.gif)
83622-42-8
78 suppliers
$55.00/250mg
![Bromochloromethane](/CAS/GIF/74-97-5.gif)
74-97-5
2 suppliers
$15.00/25 g
![2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane](/CAS/GIF/61676-62-8.gif)
61676-62-8
311 suppliers
$10.00/5g
![2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane](/CAS/GIF/83622-42-8.gif)
83622-42-8
78 suppliers
$55.00/250mg