5-METHYL-2-PHENY-1,3,2 DIOXABORINANE-5-CARBOXYLIC ACID synthesis

Yield:839720-60-4 98%

Reaction Conditions:

in tetrahydrofuran at 20; for 3 h;

Steps:

1 Example 1

Phenyl boronic acid which is an example of the compound shown by (a) in FIG. 3A solution of (2.434 g, 20 mmol) in tetrahydrofuran (15 ml) wasIt is added to a tetrahydrofuran solution (20 ml) of 2,2-bishydroxymethylpropanoic acid (2.684 g, 20 mmol) which is an example of the compound shown in (b) in FIG.It was allowed to react at room temperature for 3 hours.After removing the solvent with an evaporatorToluene was added for azeotropic dehydration to obtain a white precipitate.The white precipitate is washed with pentane,It is a substance corresponding to the compound of (c) in FIG.5-Methyl-2phenyl-1,3,2-dioxaborinane-5-carboxylic acid (4.2117 g, 19.1 mmol, yield 98%)

References:

JP2019/31487,2019,A Location in patent:Paragraph 0026; 0027