N-(5-broMo-2-chloro-4-(ethylaMino)pyridin-3-yl)-2-cyanoacetaMide synthesis

3synthesis methods

Product Name:N-(5-broMo-2-chloro-4-(ethylaMino)pyridin-3-yl)-2-cyanoacetaMide
CAS Number:842144-04-1
Molecular formula:C10H10BrClN4O
Molecular Weight:317.57

842144-03-0 Synthesis

5-broMo-2-chloro-N-ethylpyridine-3,4-diaMine

842144-03-0
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$362.00/100mg

372-09-8
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$20.00/25g

N-(5-broMo-2-chloro-4-(ethylaMino)pyridin-3-yl)-2-cyanoacetaMide

842144-04-1
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Yield:842144-04-1 100%

Reaction Conditions:

with 4-methyl-morpholine;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide at 0 - 20; for 3 h;Inert atmosphere;

References:

Heerding, Dirk A.;Rhodes, Nelson;Leber, Jack D.;Clark, Tammy J.;Keenan, Richard M.;Lafrance, Louis V.;Li, Mei;Safonov, Igor G.;Takata, Dennis T.;Venslavsky, Joseph W.;Yamashita, Dennis S.;Choudhry, Anthony E.;Copeland, Robert A.;Lai, Zhihong;Schaber, Michael D.;Tummino, Peter J.;Strum, Susan L.;Wood, Edgar R.;Duckett, Derek R.;Eberwein, Derek;Knick, Victoria B.;Lansing, Timothy J.;McConnell, Randy T.;Zhang, ShuYun;Minthorn, Elisabeth A.;Concha, Nestor O.;Warren, Gregory L.;Kumar, Rakesh [Journal of Medicinal Chemistry,2008,vol. 51,# 18,p. 5663 - 5679] Location in patent:experimental part

607371-01-7
33 suppliers
$124.00/250mg

842144-04-1
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References

31872-63-6 Synthesis

31872-63-6
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842144-04-1
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References