![](/CAS/20150408/GIF/844500-75-0.gif)
Methyl (4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbaMate synthesis
- Product Name:Methyl (4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbaMate
- CAS Number:844500-75-0
- Molecular formula:C14H20BNO4
- Molecular Weight:277.12
![Methyl chloroformate](/CAS/GIF/79-22-1.gif)
79-22-1
2 suppliers
$38.00/1000g
![4-Aminophenylboronic acid pinacol ester](/CAS/GIF/214360-73-3.gif)
214360-73-3
328 suppliers
$8.00/1g
![Methyl (4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbaMate](/CAS/20150408/GIF/844500-75-0.gif)
844500-75-0
35 suppliers
inquiry
Yield:844500-75-0 100%
Reaction Conditions:
with pyridine in 1,2-dichloro-ethane at 0 - 60;
Steps:
93.1
Step 1: Preparation of methyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate A mixture of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (150 mg, 0.685 mmol) and pyridine (0.277 mL, 3.43 mmol) in 1,2-dichloroethane (3.5 mL) was added methyl chloroformate (0.058 mL, 0.754 mmol) at 0° C. and stirred at 60° C. for 6 hours. The mixture was diluted with AcOEt, washed with 1N HCl, brine, dried over Na2SO4, then filtrated through Celite pad. The filtrate was concentrated to afford the desired product (198 mg, quant) as a pale yellow oil. 1HNMR (CDCl3) 400 MHz δ: 7.75 (d, J=8.6 Hz, 2H), 7.39 (d, J=8.6 Hz, 2H), 6.64 (br s, 1H), 3.78 (s, 3H), 1.34 (s, 12H).
References:
US2012/108574,2012,A1 Location in patent:Page/Page column 135-136
![methyl N-(4-bromophenyl)carbamate](/CAS/20200331/GIF/25203-36-5.gif)
25203-36-5
10 suppliers
$134.00/250mg
![Bis(pinacolato)diboron](/CAS/20180808/GIF/73183-34-3.gif)
73183-34-3
564 suppliers
$6.00/5g
![Methyl (4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbaMate](/CAS/20150408/GIF/844500-75-0.gif)
844500-75-0
35 suppliers
inquiry
![N-PHENYLCARBAMIC ACID METHYL ESTER](/CAS/GIF/2603-10-3.gif)
2603-10-3
55 suppliers
$17.67/1gm:
![Bis(pinacolato)diboron](/CAS/20180808/GIF/73183-34-3.gif)
73183-34-3
564 suppliers
$6.00/5g
![Methyl (4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbaMate](/CAS/20150408/GIF/844500-75-0.gif)
844500-75-0
35 suppliers
inquiry
![Carbamic acid, N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, methyl ester](/CAS/20210111/GIF/1384313-34-1.gif)
1384313-34-1
0 suppliers
inquiry
![Methyl (3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbaMate](/CAS/20150408/GIF/1384313-38-5.gif)
1384313-38-5
14 suppliers
inquiry