1-(2-fluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid(SALTDATA: FREE) synthesis
- Product Name:1-(2-fluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid(SALTDATA: FREE)
- CAS Number:845546-24-9
- Molecular formula:C12H12FNO3
- Molecular Weight:237.23
![3-Pyrrolidinecarboxylic acid, 1-[(2-fluorophenyl)methyl]-5-oxo-, methyl ester](/CAS/20210305/GIF/1171491-08-9.gif)
1171491-08-9
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845546-24-9
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Yield:845546-24-9 25 g
Reaction Conditions:
with water;sodium hydroxide in methanol;
Steps:
10.2 Step 2. Synthesis of compound 3
A solution of NaOH (12.0 g, 300 mmol) in water (70 mL), was added to a solution of compound 2 (28.7 g, 98 mmol) in MeOH (200 mL). the resulted mixture was stirred overnight and concentrated under reduced pressure. The residue was acidified with aq.1 M HCl to pH 3-4. The formed precipitate was filtered off, washed with water and dried under deduced pressure to afford compound 3 (25 g, 90%) as a white solid that was used for the next step without further purification.
References:
WO2020/172565,2020,A1 Location in patent:Page/Page column 186
20781-20-8
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845546-24-9
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617-52-7
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845546-24-9
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