2-Benzofurancarboxylic acid, 2,3-dihydro-5-iodo-, methyl ester synthesis
- Product Name:2-Benzofurancarboxylic acid, 2,3-dihydro-5-iodo-, methyl ester
- CAS Number:847949-06-8
- Molecular formula:C10H9IO3
- Molecular Weight:304.08
847949-05-7
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Yield:847949-06-8 0.9 g
Reaction Conditions:
with dichlorosulfoxide in methanol at 20; for 1 h;
Steps:
Preparation of compound 42
Compound 41 (1 g, 3.45 mmol) was dissolved in methanol (10 mL) followed by the addition of thionyl chloride (1.23 g, 10.34 mmol). The reaction mixture was stirred at room temperature for 1 hour, then directly concentrated in vacuo and extracted with dichloromethane. The organic phase was dried, filtered, concentrated in vacuo, and passed through a silica gel column to obtain compound 42 as a white solid (0.9 g, yield 86%).
References:
WO2022/63278,2022,A1 Location in patent:Page/Page column 55-56
1914-60-9
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