Carbamic acid, [(3S)-1-[[[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]methylamino]carbonyl]-3-pyrrolidinyl]methyl-, 1,1-dimethylethyl ester (9CI) synthesis

1synthesis methods

Product Name:Carbamic acid, [(3S)-1-[[[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]methylamino]carbonyl]-3-pyrrolidinyl]methyl-, 1,1-dimethylethyl ester (9CI)
CAS Number:848464-75-5
Molecular formula:C18H34N4O4
Molecular Weight:370.49

(3R)-(-)-1-BENZYL-3-(METHYLAMINO)PYRROLIDINE

144043-17-4
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$45.00/100mg

Carbamic acid, [(3S)-1-[[[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]methylamino]carbonyl]-3-pyrrolidinyl]methyl-, 1,1-dimethylethyl ester (9CI)

848464-75-5
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: tetrahydrofuran
2: dimethylformamide / 100 °C
3: ammonium formate / Pd/C / ethanol / Heating
4: NaBH₃CN / methanol

References:

Grey, Jonathan;Dyck, Brian;Rowbottom, Martin W.;Tamiya, Junko;Vickers, Troy D.;Zhang, Mingzhu;Zhao, Liren;Heise, Christopher E.;Schwarz, David;Saunders, John;Goodfellow, Val S. [Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,# 4,p. 999 - 1004]