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848580-34-7

2,8-Diazaspiro[4.5]decan-1-one, 2-methyl-, hydrochloride (1:1) synthesis

1synthesis methods
1061683-09-7 Synthesis
2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 2-methyl-1-oxo-, 1,1-dimethylethyl ester

1061683-09-7
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Yield: 98.4%

Reaction Conditions:

with hydrogenchloride in methanol at 0 - 20; for 5.5 h;

References:

ELI LILLY AND COMPANY;LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.;ZHOU, Guo Qiang WO2018/148856, 2018, A1 Location in patent:Page/Page column 6