Carbamic acid, N-[(1R)-3-bromo-1-methyl-2-oxopropyl]-, phenylmethyl ester synthesis

1synthesis methods

Product Name:Carbamic acid, N-[(1R)-3-bromo-1-methyl-2-oxopropyl]-, phenylmethyl ester
CAS Number:852248-32-9
Molecular formula:C12H14BrNO3
Molecular Weight:300.15

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Carbamic acid, N-[(1R)-3-bromo-1-methyl-2-oxopropyl]-, phenylmethyl ester

852248-32-9
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: Et₃N; EtOCOCl / diethyl ether; tetrahydrofuran / 0.5 h / -25 °C
1.2: 90 percent / diethyl ether; tetrahydrofuran / 3 h / -10 - 20 °C
2.1: 97 percent / aq. HBr; glacial acetic acid / 1 h

References:

Bures, Filip;Kulhanek, Jiri [Tetrahedron Asymmetry,2005,vol. 16,# 7,p. 1347 - 1354]