ChemicalBook CAS DataBase List 3-((4-METHYLPIPERAZIN-1-YL)METHYL)-5-(TRIFLUOROMETHYL)ANILINE

3-((4-METHYLPIPERAZIN-1-YL)METHYL)-5-(TRIFLUOROMETHYL)ANILINE synthesis

9synthesis methods

Product Name:3-((4-METHYLPIPERAZIN-1-YL)METHYL)-5-(TRIFLUOROMETHYL)ANILINE
CAS Number:853296-94-3
Molecular formula:C13H18F3N3
Molecular Weight:273.3

Piperazine, 1-methyl-4-[[3-nitro-5-(trifluoromethyl)phenyl]methyl]-

942076-92-8
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3-((4-METHYLPIPERAZIN-1-YL)METHYL)-5-(TRIFLUOROMETHYL)ANILINE

853296-94-3
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Yield:853296-94-3 96.1%

Reaction Conditions:

with palladium on activated charcoal in ethanol at 50;Inert atmosphere;

Steps:

23.4 Preparation of 3-((4-methylpiperazin-1-yl) methyl)-5-(trifluoromethyl)

To a solution of 1-methyl-4-(3-nitro-5-(trifluoromethyl) benzyl) piperazine (2.4 g, 7.96 mmol) in 75% ethanol, 10% palladium on carbon (240 mg, 10% eq) was added. The solution afforded was replaced with nitrogen 3 times and the reaction proceeded at 50° C. After completion of the reaction, the solution was filtered under reduced pressure, evaporated to dryness to obtain the desired product as a white solid (2.1 g, 96.1% yield). MS m/z (ESI): 274.1 [M+H].

References:

US2017/305920,2017,A1 Location in patent:Page/Page column 0213

(3-nitro-5-(trifluoromethyl)phenyl)-(4-methylpiperazin-1-yl)methanone

853296-95-4
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853296-94-3
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References

Methanone, [3-amino-5-(trifluoromethyl)phenyl](4-methyl-1-piperazinyl)-

853296-96-5
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853296-94-3
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References

[3-NITRO-5-(TRIFLUOROMETHYL)PHENYL]METHANOL

180146-66-1
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853296-94-3
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References

328-80-3 Synthesis

328-80-3
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$6.00/1g

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References