(S)-5-(Aminomethyl)-3-(4-bromo-3-fluorophenyl)oxazolidin-2-one synthesis

6synthesis methods

Product Name:(S)-5-(Aminomethyl)-3-(4-bromo-3-fluorophenyl)oxazolidin-2-one
CAS Number:856677-03-7
Molecular formula:C10H10BrFN2O2
Molecular Weight:289.1

(S)-2-((3-(4-bromo-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione

1032827-78-3
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(S)-5-(Aminomethyl)-3-(4-bromo-3-fluorophenyl)oxazolidin-2-one

856677-03-7
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Yield:856677-03-7 100%

Reaction Conditions:

with hydrazine hydrate monohydrate in ethanol at 90;

Steps:

1.19

To a solution of Intermediate-14 (11 g, 26.3 mmol) in EtOH (150 mL) was added NH₂NH₂-H₂O (85%, 7.7 g, 131 mmol). The mixture was stirred at 90° C. overnight. The mixture was filtered and rinsed with EtOH (2×50 mL). The filtrate was concentrated to give Intermediate-15 (7.6 g, yield 100%). MS (ESI+) m/z 289 ([M+1]⁺).

References:

US2021/403463,2021,A1 Location in patent:Paragraph 0231

444335-16-4 Synthesis